Is Neptune square MC a no go?

I'm seriously considering a move to start a new day spa business in San Diego. I'm not experienced in relocation astrology, but from what I've read, the Neptune square MC aspect isn't good for career issues. What orbs are used? If I move up north to Los Angeles the orb widens, but it's 1'31" which I would think still applies...

Since starting a new career/business in Sand Diego will be a key part of my life, would this move be a disaster?

Also, any thoughts on having Venus and Mercury in 12th house? I"ve also read bad things about this...

Thanks!

bump

I'm confused. You seem to have posted a birth chart. Or is this simply a relocation chart? Generally in a relocation chart, you have to move a long ways away from your birth location to see much difference.