I think it will all mean the same as it has meant before and will mean in the future. Planets have changed signs before. Transits might change. We might be affected on a generational level, or we might have to look at the birth charts of people born now in more detail, but everyone has to do that to their children.
In short, it means we're getting older and the world is moving on without us. We will find it harder to understand some positions as we are 'dated' from an era when Neptune and Pluto always used to sextile. Those were the days!