What in someones chart would show a separation from ones mother…. ?
If you are referring to your personal 'mother issues', your pseudonym might well provide a starting point, especially if in harsh aspect.
Uranus, as modern ruler Aquarius, and in harsh aspect with natal Moon is a
cert. for 'maternal clashes' because Uranus cannot come up to the expectations that a natal Moon imagines for its child/mother. A transit from Uranus to natal Moon can indicate 'temporary clashes' that, if not settled, can show a tendency to become permanent.
Any harsh aspect with natal Moon will show how the child experiences the mother figure and its attitude towards it.
There is an calculated non-physical astrological point called Black Moon Lilith. Its MEAN position
lilth:in astro. com/astrotheme charts) in harsh aspect, especially to natal Moon, can offer information regarding any 'non-physical (emotional) attachment' with the biological mother.
can turn away and disconnect from that which it experiences as emotionally hurtful, e.g. unseen, non- existent, abandonement, neglect, yet because it actually cares so much and can't/won't show its true feeling.
Saturn can also show difficulties with 'parental figures'. It can show 'the shutting down' of manifested association, according to the manner of the strength in which one's own position works.
and a mother with drug addiction and homelessness
You're looking at aspects with Neptune with 'addiction', and possible influences from the 4th (home) or 12th (loss of physical realism) houses with homeless situation.
Pisces, as a sign, can also be relevant, especially with its modern ruler Neptune now transiting the sign.
Are you perhaps of the Uranus-Neptune (with or without Saturn) conjunction in Capricorn/Aquarius generation?