Hi Tobby. I'm assuming that the birth time isn't known. I think the first thing is to look at Mars in Aries and Venus in Libra and check that these are being owned and expressed as fully as possible. They are given a lot to do in this chart because they form a (single) T-square (rather than 3) to a very complex stellium. If your friend is highly aware of what her personal tastes and values are, and also of what arouses her to action, and if she can deal with any inhibitions or conflicts in these areas, then she will be better placed to deal with the demands of Saturn, Uranus and Neptune.
If you include Chiron its a Grand Cross. Its hard to even guess how this will work out in real life. Saturn and Chiron are both to do with woundedness, Chiron and Neptune can both reflect a sense of victimisation and helplessness (while Saturn and Uranus are both more self-relaint), and Uranus and Chiron both seek understanding. So its difficult to see which of these planets will be more conscious and which will be friends.
The resiliance shown elsewhere in the chart (Sun conjunct Pluto in Scorpio and Mars being in Aries) suggests that Saturn and Uranus will speak the loudest in the Grand Cross, but its far too complicated a configuration to say anything with certainty about without knowing something about the person, except that relationships are probably not always easy (partly due to confusion about how much to give and how much to take), and that there is a dynamism about your friend due to the Cross falling in cardinal signs and involving Mars.