Yes, there are 3 challenging t-squares in this chart, but I can also see a lot of trines and sextiles as well as 2 minor grand trines, also called small talent triangles, which could help ease the tensions of the squares.
The Mercury-Jupiter conjunction in Leo/5th house is potentially a very creative aspect, this person is probably a very good communicator. This conjunction is at the center of one of the small talent triangles, with the Mars-Pluto trine, as well as being in the middle of the third t-square, with Chiron and Uranus making the opposition. A complex pattern, which looks to me like one of the focus points of the chart.
What you perceive as sad and difficult is most probably the t-square between Moon, Mars and Saturn/NN, a very challenging pattern, which can make the native prone to depression, causing a lot of restrictions and frustrations. Adding to this is the opposition from Neptune to Mars, making another t-square with Saturn/NN, it is almost a Grand Cross, except the orb between Moon and Neptune is very wide with almost 12°.
Saturn closely conjunct the NN indicates that the native will experience many restrictions in this life, and he will have to learn Saturnian qualities such as patience, endurance and discipline to achieve anything.
The Moon-Saturn/NN opposition is eased by the trine-sextile to Venus. The Sun is squared by Pluto, but it also trines Uranus. The Mars-Neptune opposition is actually part of a series of sextiles, which can redirect the energy. So I think this person has many talents, as well as challenges and he will need to use these talents to deal with and overcome all the challenges in his life.