If you are an astrologer who has received a question at a time when the Ascendant is very early or very late than you need to do a couple of things. Firstly, double check all of the chart information and make sure that it is correct. Date, time, place, time zones. I have experienced several different instances of charts with early or late Ascendants where, when double-checking the information, I learned I input something incorrectly or did not change a setting in my program. Saves a lot of embarrassment when you are not interpreting the wrong chart.
Secondly, if you've double-checked the information and the Ascendant remains unchanged, you need to ask some questions from your querent. It is important to know all of the details surrounding a question, but it is especially so when the Ascendant is off. Typically these situations suggest that the querent is purposely withholding information or only asking something that is tangentially related to the question they are really wanting to ask. This often results from embarrassment or uncertainty on their part, and it is important to reassure them.
If you are a querent who has asked a question to themselves and gotten an early or late Ascendant, then you need to cut that out.