What kind of creative route do you want to take? Become an artist, writer, musician, or something else in the creative arts? Or start your own business? Or do something else, maybe something mainstream done in a creative way?
Has this kind of shakeup happened in your life before? Have you moved frequently? I ask because this sounds very Uranian, and you have Uranus right on your IC. That would suggest restlessness and/or frequent change in your home life, residence, family, that kind of thing. Did you come from a family that moved frequently, was chaotic in some way, or was simply unusual?
Uranus is currently transiting your seventh house (relationships, partnership), which means a square to your tenth (career, public reputation) and your fourth (home, family), and opposition to your first (identity). What surprises me is that this happened so recently. As an astrologer, I would expect something like this to happen, if it happens, when Uranus crosses your DC. But Uranus crossed your DC about three years ago.
However, Mars is currently applying conjunction to Uranus, having crossed your DC in just the last month and your IC a few months ago, and Venus just crossed your DC, is squaring your MC/IC and natal Uranus, and soon to go retrograde, back over your DC. I suppose that could easily be connected with the end of your relationship and the home and career dominoes falling in turn. If there were similar themes in your last solar return chart, the Uranus/Mars/Venus/DC indicators would manifest very strongly.
In any case, you know what you don't want, and it's wise to take this time to make a change for the better. Sixth house cusp in Pisces suggests that you need to do day-to-day work that fits a Pisces-like theme: intuitive, creative, maybe caring. But both the traditional ruler (Jupiter) and the modern ruler (Neptune) of your sixth house are in earth signs, which suggests a need for structure, detail, security, and practicality.
What was it about your previous work environment that didn't work for you? Was it heavy on structure and low on room for creativity? Your chart suggests you need both in your work. If you had too much structure at your last job, you might feel like throwing structure to the winds and getting purely creative--but complete lack of structure won't work for you, either.