I think Saturn will somewhat contradict what you're suggesting but I'll get to that later. I had tr. pluto square my Aries Sun (in 8th house) and it did nothing, because my identity is genuinely my own and not based on anyone's expectations of me. Pluto tends to strip away any false pretences. Tr. Uranus conjunct my Sun, virtually no change except being a bit more open and accepting help from others. Keep in mind my Sun only receives soft aspects like yours so the burden was not difficult.
Also ruler of your 11th is in the 10th house and is well aspected, suggesting change in the work place is easier to integrate. The moon is more susceptible to tr. Uranus as she is widely conjunct Uranus and receives a square from neptune. That may require attention.
When the axis receives hard aspects from pluto (I have pluto square my axis natal), you will find that a power play commences where either you are the victim or the other party is.... which in your case may mean working somewhere where you don't have to deal with bosses taking advantage of you. Your natal Saturn is in mutual reception with Pluto in capricorn. I think that is what will help you deal with losses you have from tr. Pluto.
You recently experienced Saturn returning to the 2nd house. The general lesson of your Saturn return is to hone other peoples resources and use it to build your own sense of self worth and self sufficiency. You're asked to build your own wealth of resources through your contact with others and when you do, it will be something sustainable and true, as per tr. Pluto. So you may need this push from pluto if you need to get on track.
Also, saturn will pass on the North Node. I consider that transit a great boon, since it will put you on the path of your North Node and the path of soul growth. I agree that you should pay attention to your health! Pr. Ascendant conjunct natal saturn and square its ruler pluto....
As for Pluto-Jupiter conjunction, I am not well versed but typically Jupiter in 12th means dealing with spirituality, selfless pursuits and moments of solitude to reflect and recharge.
Edit: I realized you are mostly concerned with IC-MC axis. Well... ask yourself, is the job you're currently doing true to what your cancer sun and moon need or are you just using your job to pay the bills and to give yourself a sense of security? Is there room for innovation and a chance to shine at work, as per Uranus in Leo or are you often bored? Do you know your roots and if so, can you build a strong emotional foundation from them, as per IC in capricorn? Does you home hold up to the test of time, is it stable, functional, require any repairs? I think asking yourself this will help determine what Pluto will do.