I don't see why you couldn't work from home, but your chart doesn't strongly support it. The ruler of your 10th house of vocation/ career, Venus, is in the 7th house of committed relationships. The ruler of your 4th house of "home," Mars, is in your 6th house of illness & health, service, and work. ("Work" in the sense of just-a-job or people who do work for you, like the plumber.)
The moon is another indicator of one's home. With your moon conjunct Uranus, you might even change location frequently. Moon-Uranus can give you classic "itchy feet" to the point where you might enjoy living full time in a RV (caravan) as you travel, or aboard ship.
Is staying home per se super important to you, or is the issue more like not wanting to have a boss or working in a big office setting?