Hi,
your 10th house ruler, Venus, has some challenging aspects (squares) with your Neptune and Uranus, coming from your 1st house.
Neptune can speak of several things, like idealism pushed to the limit, bordering with delusion, lying to oneself, being lied to by others... Since it is coming from the 1st house, I'd also take into account certain amount of procrastination. People with this placement are not necessarily lazy, but they do tend to waste time, due to inability to see clearly the pragmatic side of the reality - which is not the best thing for career oriented people.
Uranus in the 1st brings about certain unpredictability, rebelliousness, sudden changes that will affect your career. The career choice is very important here. If you decide to go for traditional, institutional options, you may find that not only you could be unhappy there, but that others may perceive you as not a great match for the job. However, if you are inspired by idealistic (activism?) work and are not stressed out with sudden changes, interruptions and hectic dynamic, you may find easier to integrate your career with your personality.
This is further strengthened by your Mars in the 10th - raw energy, need for a dynamic environment (probably even a certain amount of physical engagement at work), but also need for and individualistic approach. You may like to work together with other people , but you do need a certain amount of autonomy.
Another thing, your North node is in the 10th, which means that it is a place where you really need to make an effort. South node is a place where we tend to hide to avoid doing what needs to be done (the house the North node is placed), because this is where we feel comfortable since we have learned the ropes at some point in our previous lives. In your case that is the 4th house. The need to invest time, energy and money in a home, or instance, can be so overwhelming that it clouds a true priority, which is dealing with the 10th house issues.
Given the fact that your 10th house ruler is in the 9th house, this cosines with the 4th house related things is really pulling you back, since this placement speaks of a career that is related to travelling, or getting to know and work with foreign cultures in some capacity, studying & teaching & publishing (underlined by Venus conjuction Mercury), finding higher meanings...
You could chose a career that is connected with some sort of activism that will require a lot of moving about and dealing with foreigners. Nowdays there are many ways to communicate, sop when I say publishing&writing it can be blogging, vlogging...