Well, let me simply state that none of our traditionalist practitioners, none of our Vedic practitioners, and few of our Modernist practitioners, will add this as a "new sign" (or, with the Vedics, as a new "rashi) to the basic zodiacal formats they currently use.
I believe that, as a starry constellation, Ophiucus DOES have a sub-influence (through the ascendant connecting with one of its stars, or the Sun or the Moon or the Part of Fortune, having a similar connection with the constellation via one of its stars), but so does Orion, so does Pegasus, so does Cetus, and so do dozens of other starry constellations, when they have a connection through one of their stars with the ascendant or Sun or Moon. But I do NOT accept Ophiucus as a 13th tropical SIGN-no way-and the great majority of practitioners (of the various astrological systems) don't-and won't-either...