Sister: unstable life, worried about her.

-Is she ok, or a my worried just because she is diferent than me, and despite all, she is and will be ok? What does the chart says about her?

-How can I help her? Will I be able to do so or is just one of those sad situations that one just has to accept and see the destrucction from afar? Will she change? When?

-Will she loose her kids?
-What is the best aproach, actitude to deal with this situation, to voice my concern to her?

She is a Virgo (I do not know her hour of birth). I am a Cancer, Asc. Virgo.

If she's not complaining or asking for help then, all you can do is wish them well. Otherwise you are interfering and will be resented and make things worse. Learn to live and let live.