Roughly speaking, look at the Mercury for both when considering friendship.
The Mercury of both people are inconjunct (or as would be traditionally said, in aversion). They don't "see" each other and so friendship capabilities will be strained because of that. Such as by not even having the same ideas of what friendship really means.
The chart on the outside has their Mars conjunct the Mercury of the chart on the inside. So that will cause agitation to the friendship capabilities too, particularly to the person whose chart is the inside chart.
Further the north node of the outside chart is conjunct the 6th cusp of the inside chart which will activate and bring about 6th house things in the relationship (which aren't really conducive to friendship, the 6th house is a place of enemies among other things).
From a quick glance the person on the inside isn't so well served in the friendship as the person on the outside.
You can use basic relationship synastry too for friendships. Just pay more attention to Mercury specifically than you normally would.