First of all, so nice of you to come on a forum to help your friend. Mental health is such a misunderstood area of life, and most people don't try to understand. I have a lot of thoughts on the subject ... mostly that in other cultures, depression and anxiety are viewed as spiritual growth on the part of the individual. Also, sometimes its an indication that you are not being true to yourself, or you're on the wrong path.
That in mind, I am not expert. I have only been studying astrology for a few months, but I would really like to get better. This is what I notice in the chart. Is he in a serious relationship? Or does he struggle with relationships? He has his moon squaring his venus, with his sun (ego) in the seventh house of relationships. It seems like relationships would be key in how he perceives his view of himself. He also has Mars in his seventh which can attract very aggressive energy in relationships. I have this placement and my relationships have been far from healthy in the past. He has Chiron in the twelfth in libra ... to me that looks like subconscious wounding from relationships that may be hidden from him since it is in the twelfth. That Mars conjunct the descendant can make you apprehensive about making decisions and taking initiative. Like I said, I have this placement and I have a lot of anxiety sometimes. I attract assertive partners to help me learn how to be more assertive. His moon in capricorn could also be a factor. I have four planets in capricorn and sometimes Saturn's energy can be very oppressive and overbearing. It can make you feel like breaking because of the huge weight on your shoulders, so you just give up. Moon is considered in detriment in Capricorn, so not always an easy placement emotionally. His chart is really interesting...Hope this helped somehow. Let me know what you think.