The Saturn square might make it hard to find or keep a job. Saturn, being in the 7th, suggests to me that this difficulty stems from having problems with other people, co-workers, supervisors, clients etc. especially on an emotional level (Cancer). Perhaps your socio-emotional skills need work. What makes this even more challenging is that, with MC’s ruler, Venus, in Gemini right on the DC, I think working with people is something that you want and maybe even destined to do. I think with enough hard work, these difficulties will pay off and you will earn your reward. You aren’t doomed.
Jupiter in the 4th opposite the MC makes me think go through periods of intense hard worker, throwing your all into it, and periods of intense laziness, preferring to stay at home. Especially since this is the Aries/Libra axis we’re talking, I’m guessing it can be difficult to find a balance
Neptune in the 12th House Sagittarius acts as a benefactor here. I would use your imagination and intuition, maybe even whatever spiritual practice you’re into, to aid you in your career.