My mother was told by her doctors that she had one of the highest pain threshold they'd ever seen. She had a Virgo Ascendant, with Ascendant ruler, Mercury in Virgo conjunct Neptune in Virgo in the 1st house.
I've lived with pain that most people would be on a constant diet of Vicodin for. The ruler of my 6th is Mercury Rx in Sag in the 12th house ( Pisces/Neptune influence here, too, since 12th house)