Traditionally, the 12th is the house of "hidden enemies," meaning back-stabbers, vs. the 7th house of "open enemies"-- the ones (if any) you know you've got. Hobbies are a 5th house matter. The 6th house includes illness and health, and people who work for you in some capacity. By extension, in modern astrology it includes work and the principle of service, such as volunteering or working in the service sector. It also rules small animals like dogs and cats (vs. livestock.)
I wouldn't pay huge amounts of attention to fast-moving planets (like sun, moon, Mercury, Venus) making transiting aspects to your vertex unless it's a conjunction. If you think about it, there are all kinds of aspects to your vertex on a frequent basis. They can't all mean "fateful enocunters" or "fateful events."
But by all means-- see what happens when Venus trines your vertex.