Hi. So you say that the pattern begins with you meeting someone who is in a bad way - who needs your help. Does this apply to the work colleague who has started ignoring you lately? If this is the way that these friendships always start, some of the following points may be worth you reflecting on.
Your mother's preoccupation with what might go wrong, and her subsequent compulsion to protect you, would have obscured other facets of the child-parent bond. You perhaps didn't feel affirmed for who you are and what you can do, and this would probably account for much of the resentment that you felt/feel towards her. Having not been affirmed, you believe that you have little inherent worth (as you noted in one of your posts), and that the only people who will want to bond with you are those who really need something from you. There are various possible implications of this which spring to mind: one is that if the friendship is based on the need of the friend, then it won't necessarily last beyond the point where the friend's need has been met; another is that the friend may begin to feel uncomfortable about the dynamic, because they have been cast in the role of the needy one - perhaps even feeling on some level that you have used her or him to feed your need to be needed; another is that you are wearing an invisible badge that says, 'Use me and then discard me - I'm not worth more respect than that', and so you attract people who don't carry the same amount of love and loyalty in their heart as you do.
So one thing you could do would be to carry on with the self-esteem work you've been doing, and try to form friendships which are not based on the friend's overt need, and also not based on your need to be needed, or a sense that you have to be giving, giving, giving to justify your place in the friendship.
Whether this pattern has any karmic basis I wouldn't like to speculate. By whichever means it came to be established in your life and ingrained in your psyche, you can choose to step out of it and allow it to gradually dissolve, or you can remain entrenched in it and continually reconstellate it. In so far as you can step out of it, you will get instant relief, though you will need to remain alert to not start identifying with it again. The predisposition shown in the chart is not who you are. You are the pure consciousness out of which thoughts, feelings and emotions arise according to the predisposition reflected by the state of your celestial environment at birth.
If we strive to overcome the challenges in our natal charts, we just switch one drama for a seemingly more evolved one, denying ourselves the peace which comes from no longer identifying our conditioning as 'I'. The aspects will not remain at your very core. They are not your very core; they never have been and never will be. At your very core is peace and tranquility - pure life, pure consciousness. Your ego will tell you that only it knows how to survive or resolve this or that drama, but it will always lead you into yet another drama. The ego is founded on self-protective instincts, and so will never surrender to the tranquility at your core.
In this sense astrology is irrelevant. It is a toy for the ego which may help some people to get leverage against blind spots, but which at some point becomes a distraction from the issue which lies at the heart of every human life - whether to cling to a sense of separateness, or to be fully alive (thus living 'life' rather than 'my life').
From a place of stillness, you make different decisions. You may not help someone you would have helped previously. Trust the stillness, not your ego. I recommend Eckhart Tolle for guidance in finding the place fo stillness within. He has some stuff on You Tube, including a video called 'The Most Powerful Video on Spirituality' (I don't think he gave it this label). His book 'A New Earth' is wonderful and well worth a read. There was an audio book of it on You Tube which you can donwload onto your phone if you have a You Tube app which does this. I think if you play it on You Tube you get lots of ad breaks apparantly.
Making peace with your aloneness could be a significant step forward, but the ego will still be in control of that acceptance. The ego is still getting you into the same dynamic, and is now reinforced in some ways because you have added to your sense of identity 'I am a person who is destined to be lonely.' So keep going - keep relaxing into the stillness until you don't identify with anything.