I agree with you, it is only because Ehab worded the question looking like Barca are the home team; so I thought Barca would be Favourites. Madrid are the FAV.odds slightly in favour of madrid as fav.
RealMadrid to win 3-1.
Using Frawley:
Madrid ASC (White) vs Barca DSC (Red/Blue)
Mercury in 6th vs Jupiter in 5th.
Using Planet Assignment:
Moon in 11th vs Mars in 5th. Moon moves into 10th, Mars into 4th. Moon is always stronger.