Are you still certified as a nurse? Could you build on that experience?
Ultimately, I think you're to end up a healer, a teacher, or both. In what way, I'm not sure, but I would guess an alternative way. Modern MC ruler Neptune with Uranus suggests out of the box, spiritual, something along those lines. But since you have Saturn in that lineup too, it's no accident that you started with a career in conventional medicine. If you still have nursing certification, that could help legitimate something you do that's more off the beaten path. A couple of examples in people I know: a therapist who added hypnotherapy and reiki to her practice; an herbalist who is also a nurse.
With traditional MC ruler Jupiter in Cancer, and that being your rising sign, too, you've got a healer message. Especially with that Jupiter/Chiron conjunction. I think ultimately, what you give the world will come out of your own being and your own healing experiences, whatever they are.
That may not mean anything in practical terms if you're talking about what to do right now. But since you asked what your dharma is, I think that's an important question to address.
Pisces MC is often associated with multiple careers. And with just drifting into something, so eventually you'll say, well, I guess I had a career in ____. In that light, there really isn't a best career for Pisces MC people. It's whatever you intuitively swim into.
As far as starting a business goes, anything you're interested in could work with your chart. The questions are the practical ones: do you have a solid business plan? Enough seed money? Enough knowledge of the market and experience in the field to make it work? Are you advertising in a way that reaches the right people? Charging the right amount of money to support your business and get customers who are willing and able to pay it?
Trying to make a go of it during a worldwide economic collapse is a whole other wrinkle. You could have a fine business plan for normal economic conditions and not have it work under current conditions. And, even under normal economic conditions, the fact remains that the majority of new businesses fail within five years. Small businesses aren't necessarily hard to start, but they're prohibitively difficult to sustain.
If you've tried to run these businesses all on your own, that might be another factor in their failure. People who start businesses bring the qualities found in their birth charts to those businesses. Your chart works well in some ways for being an entrepreneur: lots of cardinal energy (cardinal signs are the ones that start things), lots of earth, allowing for practicality and grounding, plenty of water and a dose of air to facilitate making connections. But you don't have any fire. It takes fire energy to spark an idea into action.
That doesn't mean you can't ever be a business owner, but it would probably work best if you partnered with someone who brings the fire element to it. If they're strong on fire but weak on earth or water, it could be a match made in heaven: they would need your strong elements as much as you need theirs.