Hi,
If my counting is correct, there are two sesquiquadrates to Pluto:
One from Moon (that is also conjunct Sun), ruler Ascendant in 10th,
one from Jupiter, ruler 6th house, in 12th.
As Moon and Jupiter is in a square aspect and are each 135* to a 3rd planet, you have a configuration that is called 'Thor's Hammer'.
I look at the 135* aspect as a 90+45*, which takes on a slightly different perspective than that of Krewster. I interpret it as the challenge that requires the necessary effort in order to, yet may not, achieve and succeed. In the chart shown it's an interesting 'personal' combination because there is involvement between the 1st,5th and 6th houses to the 10th.
As an example only:
The Ascendant and 6th house have strong associations with the physical body. Their rulers are in square aspect to the planet of willpower in overcoming the odds, in its own sign albeit retrograde.
The configuration might suggest a physicality that has an effect upon one's ability to (find) work(6th house) and succeed in a career life (10th house). An individual could find the effort of the challenge too much and accept that (s)he'll not make much of him/herself because of a lack of belief(Jupiter) in one's self(Sun) .
OR: the very fact of the physical challenge upon one's willlpower to overcome the odds, together with one's belief in one's abilties, could spur one on to make the necessary effort required to achieve success.
Other aspects will play their role, of course. They are the nails. It's merely a question of how the hammer is used.....to knock character and circumstances into or out of shape???