The grand cross is in the succedent houses so it will not be as troublesome had they been on the angles. Angles are typically active energy areas and outside things may happen with these.
To sort of figure out what direction things are coming from you look at house location and rulership. Too you can see traditional rulership.
Did you have your natal somewhere? what natal house is rising?
Remember that everyone this year will have some level of this square tension in their chart due to the outer planets moving into early Cardinal signs.
Couple things. YOu want to look for repeat aspects like if you have sun in Saturn in an aspect in your natal chart and see them aspected again in the solar it may imply that natal potential playing out. If they are in a postive natal aspect the negative may be challenging but it will ultimately turn out positive.
The solar is really just one tool in prediction and to see a major event you need at minimum three or more indicators of the same theme. Using solar arcs and progressions to back it up.
Only one note and I would prefer to see your natal, we can see a challenge with the ruler of the 7th or relationship opposed to ruler of 1st or self. Uranus presents unexpected and abrupt challenges in relationship. The sun in the 8th emphasises others resources, wills, death and rebirth, transformation. Sun with saturn is a contraining force and as it rules the solar 12th this might imply some level of confinement or things hidden to you. Just continue in this vein of looking at where the planet it, what house it rules and traditional ruler ship ie
Sun=males, ego, health, energy rules 7th of relationship in 8th of resources opposes jupiter=legal, state of mind, beneficial, expansion in first house of self rules career 10 authority and reputation as well as hopes and dreams 11, money from career (2nd from the 10th) friends, larger social experience, and things you can not control.
This sounds more like a career situation than a physical situation.
Where is the 6th house ruler? Moon ruler the 6th house ruler and it is in 5th of children. Pluto aspects and the traditional ruler of Pluto is the 8th of birth or procreative sex. Though Pluto opposes this simply could imply again this challenge to the moon. Thus health may be centered on procreation it appears. Often times you see challenging aspect on happy occasions. A challenge can be a wedding or the birth of a child as it is increased responsibility.
Please add in your natal. You now have me a tad worried with comments about 'death as a relief'.