12th house significator for self and career

chart cast for 8/19/2014 7:57am Eugene, OR - Do I have a chance at getting job?
My question is how much of a problem is a significator in the 12th house when other factors are strong?

MC 10 Gemini
ASC 14 Virgo
Moon in 10th in Gemini 20 degrees
PoF in 10th 8 degrees cancer
Mercury in 12th in Virgo
Moon will sextile Sun in Leo in 12th - 6 degrees applying

Significator for Self and career is same - good
Mercury in Virgo - strong candidate
Moon in 10th - good, 'at hand'
Significator in 12th - not going to happen?
 
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