Interesting things here - there's definitely a predominant theme of change-ups involving work. The SR 6th H cusp, Merc + Uranus conjunct your natal MC - wow! The alignment of the nodes with SR MC/IC axis really emphasizes the theme of work + home in the coming year. No doubt "home" is on your mind with SR AC being brought to natal 4th. As I mentioned earlier, possibility for a move (likely connected to work or some kind of organization/3rd party) is there, although whether or not you'll
feel at home is another story (not saying you won't - but the Moon/Nept conjunction could lend some illusion or confusion and the SR Scorpio AC and SR Moon in Pisces can heighten the intensity of the feelings - something your Leo Moon/AC might not be too comfortable with!
). SR 12th H cusp conjunct natal IC and the nodal alignment I mentioned earlier indicates that there could be something karmic connected to "home" this year. Lots of mutable energy so hard to say how this will play out - and you may not see much movement until the last quarter of your SR year. Best of luck to you - as the zen saying goes, every step of the journey is the journey.