Yes, it looks like this is going to be a big year for you, and a good one too. My happiest years have been when the SR Ascendant's in Sagittarius. Sun-Moon aspects especially squares, conjunctions and oppositions are supposed to represent climatic years and this, I have also found to be true.
I'd say this 'climax' is most likely to occur in the area of relationships: Sun in the 7th opposition Moon in the 1st. This doesn't necessarily indicate anything romantic. Maybe there will be some conflict between asserting yourself and what you instinctively feel and believe (the Moon is in Sagittarius) and maintianing your social connections. With Mars in the 7th exactly sextile Venus in the 5th however there is a very strong possibility that romance could be involved. I agree that someone karmic is likely to come into your life: Uranus conjunct the North Node. This person will shake things up for you and leave a big impact.
The Moon is conjunct your natal Uranus too... very interesting. With the Ascendant in your 6th house, this could indicate health problems of some sort: likely disruptive and psychosomatic.
Chart rulers in the 10th house: this is good, especially if you spend a lot of time in the public eye.
Another interesting thing is Mars right on your natal Ascendant: do you know what that could represent?