Including your combo chart
A couple of things I see - one of the problems seems to be caused by Uranus having been stationed on your IC, opposite your midheaven for some months - Uranus can produce a kind of strong desire to uproot in this position like you are thinking of both going forward but being stuck or pulled back into some past pattern also - likely to be a family vs work theme with this one.
Another one is progressed Mars square Neptune - this can actually cause you to doubt what you are doing feeling unsure it's "right" or that you have the right to do it and there may be confusion and discouragement coming from various corners. It is a long-term progression so you will be dealing with it for a while. Try to see if you can adjust your way of going about acting (specifically, or even "doing") if what you are used to isn't working particularly well in the present.
Saturn itself is not doing too much at the moment but it will be crossing your (and mine being in nearly the same degree) Ascendant a few months from now - Saturn in 12H can cause some unconscious confusion and is a somewhat difficult position depending on how you handle compulsions and such normally. It is also trine your progressed Sun at the moment but the trine should be constructive if anything although you might feel like you have to slow down and reevaluate everything if you had been going at a faster pace before - Saturn will linger around these degrees for the next I think month and a half so you might continue to feel the slowed down effect for some weeks yet.
The other big one is Pluto in the 1st house which you've had since I'd say 2014 and this one demands a reworking of the personality and the way you go about doing things and dealing with people. You probably know about this and have asked about it a few times already so only touching on it.