I agree with what has been said about the twelfth house (above). Essentially, what Crystalclear is describing is a curse question. A "curse" can simply be when someone close to the querent is ill-wishing them and the close spiritual bond between them is having a bad effect on them. Or it can be a magical or spiritual person who consciously puts a curse or spell on someone.
Lilly has rules for curses on pp 464-5 and 468-9 in Christian Astrology. Basically, you need the Ascendant ruler or the Ascendant itself or the Moon to be afflicted by the 12th house ruler. In other words, we would need to see an applying conjunction, square or opposition between the first and twelfth house rulers in order to say that witchcraft (or any kind of malefic magic) is definitely present. There's another rule that involves the 12th house Lord also being the Lord of the Ascendant and combust (CA pg 464)
That being said, often what prompts horary questions about curses is a run of bad luck, and the querent is searching for an explanation.
Charts like this will often show that the querent is afflicted and tortured in some way, but not cursed. In which case, a ritual that banishes negative thought forms would probably be the solution.
On the other hand, if the chart shows indications of malefic spiritual influences, a possible solution in that case would be to have an astrological magician make the querent an Algol talisman!

This would offer protection and reflect the bad energy right back on the one who cast it!