I googled Saturn conjunct Moon recently and someone asked if it relates to insanity. In the past some astrologers said it did (I don't know the validity of this).
I've looked at charts for those who were mentally ill and since there are so many types of mental illnesses that exist, I'm not sure if there are indicators in a chart for general mental illness.
I loathe making blanket statements about aspects - and even the ancients would have wanted to see something repeat at least three times for it to have predictive value.
But Moon/Saturn conjunct on an angle or in 8 in a night chart with no mitigation (hope that's enough disclaimers) can indicate death by grief of mind, or grief of mind to the point of insanity.
Now, it does that because you grew up in a war zone and were tied up and tortured and raped along with your mother and sisters, and then you watched your captors torture and kill your father and brothers (who got to watch you being tortured and violated first), then they set fire to the house, and it's a miracle you lived, and life just got worse from there.
It happens in the 'civilised' world, too. I had a client, lovely lady, who on the same day: lost her second child to leukaemia, the child was age 3, she'd lost the first to leukaemia two years before, was diagnosed with lupus herself, her best friend was murdered, her ex-husband had her served with papers to try and get custody of their one remaining child, and - her priest raped her in the guise of 'comforting' her. When she got out of the mental institution (are you shocked? you shouldn't be), and pursued the matter with the bishopric, the priest was promoted to bishop, and the woman was excommunicated, even though it had come out that he had quite the history of sexually abusing and raping his parishoners.
Her life was a series of tragedies both before and after that, but that was the low point.
And this was a nurse practitioner and midwife, not some uneducated git living in some Deliverance-style backwater. It happens, sadly, so you can't really dismiss it.
I've seen so many clients who've had that kind of misfortune, both in the middle east and in the west, that I'm utterly loathe to start in with explanations of karma, or choosing one's life before birth, or spiritual evolution and other such things. We're not talking about manipulative people, people trying to one-up on the 'I had the worst life' scale, we're talking about fundamentally good people caught in hideous circumstance. Life is not fair, and the world is not just.
When you've got that kind of configuration, it may lead to mental illness, but I'm loathe to call mental illness the basic problem. It's usually not, nor is the root of it psychic. It's just that tragedy after tragedy eventually takes its toll and drives you mad.
For actual mental imbalance that doesn't seem to come out of life circumstances, you'd want to look at the Moon, Mercury, and the almuten of the two, probably the ascendant and ascendant ruler as well (this can be helpful in distinguishing if an illness is of the soul or of the body), and the 8th, 6th, and 12th houses.
Medical terminology was also very different to what we use now, and I don't just mean things like psistis and impostumes. A disease of the body could be cured by medical means - so if your hallucinations were curable by medical treatment, then it was a 'disease of the body'. On the other hand, a chart might show that your stomach pains were resistant to medical treatment, so that made them 'a disease of the soul' and the doctor would send you to the local priest.
Okay, I'll
try and climb down off the soapbox now.
Did you say WTF? well so did this kid. Score: 4 or 5 noias, uranus square moon, serious candidate for boderline personality disorder not only for carrying the gene but also crazy environment. Might have sun square moon or venus because daddy didnt know how to handle mom. 