Rather than engage in loony conspiracy theories, it might be good to listen to the experts. Sometimes they actually have something to say.
One reputable theory is the plane had an hypoxia event because of miscommunication between the admin and the maintenance workers. This would have resulted in a low level of oxygen that would have rendered most onboard unconscious. Possible, but I see nothing to indicate that in the Flight's natal chart (i.e. the time and place of its takeoff-I'm pretty sure I'm on the right track here because in this chart Icarus is conjunct the Vertex and Neptune is conjunct the IC-end of life situation; it was destined for the drink).
Another possibility, though highly unlikely, is a horrendous nightmare. Somehow the Captain and the Crew got locked out of the cockpit. Can anyone imagine the absolute horror that would be felt in such a situation?
However, one thing I note coming loud and clear in the chart is the triple conjunction of Mars, Vesta, and the True North Node squared by the True Black Moon. The simple explanation of a fire (probably electrical-11th House).