Hi Alice,
From the link you provided, ME is a fatigue through the muscles.
For physical disorders, the 1st and 6th houses and their rulerships are the ones to look at.
The muscles are ruled by Mars; Mars is not only ruler of the 6th house but it is also situated in Pisces, the 'weakest' of the signs dealing with the physical world. It is opposed by a retrograde Jupiter, which would suggest a general lack of, yet a need to develop an optimistic attitude towards situations/events with which one does not feel to have the energy to cope. It might seem that there is always too much (Jupiter) for one to do(Mars) alone, and need of 'support' is desired.
General tiredness can also be applied to Saturn; the weight of the world upon one, and all that, which its ruling Sign, Capricorn, knows from experience!! Saturn is in Aries, where its job is to slow down the natural Arian energy to a working pace that can be dealt with. Saturn is aspected to Mars through the 30 degree 'effort' aspect and the inconjunct to Jupiter!
It is therefore co-incidental that transiting Saturn has activated the Jupiter-Mars opposition, whilst progressed Mars is now exact degree conjunct natal Saturn.
Maybe you can help your friend in deciphering the 'psychological' aspect of her debilitation through over-tiredness.
Regards,
Friesiangal