With your sun (identity), moon (emotions), and Uranus and Pluto (powerful change forces all conjunct, you may feel like a big pressure-cooker ready to explode for most of your life! These look like difficult placements to me, so if you have managed to get through life so far as a good human being, I congratulate you.
On a soul level, we might consider that before incarnating, your soul wanted an extra helping of personal growth in this lifetime, and did not want the easy route to it! Kind of like the mountain climber who wants the more challenging route up the mountain, not the easy way up.
Let's also look at your planets bunched around your 7th house cusp (descendent.) This can suggest either that having a spouse or partner in life is very important to you (whether you have one or not), or that you view a lot of people as your enemies. The 7th house can go either way, but it suggests you being with or you being opposed to someone else. So take your choice!
I think you do have some artistic talent, with Venus in its own sign of Libra. So if nothing else, until you get your life as a whole on a better footing, the way you want it, see if you can find some small ways to "feed" those horoscope placements. Taking up a two-person game like tennis or raquet ball (or fencing--think creatively!) and something like ballroom dancing, where it's you and a dance partner, would be ideal. [Don't tell me you have two left feet, because you might meet someone, if you're signle. Don't tell me you don't play a raquet sport, because you can learn.] If you are musical, think about playing instruments, singing, accompanying, &c. with another person. The universe notices when you take small steps.
Saturn is not your enemy so much as the stern teacher all the kids hated in school-- but whom you realized later in life gave you the best lessons you ever learned. Saturn's lessons are always patience, hard work, resourcefulness, and learning to get by on very little. But he tends to reward his good students later in life.
Saturn does tend to show where we feel inadequate and not good enough. You probably have suffered from low self-esteem most of your life. This does not automatically mean there is something objectively wrong with you; merely that you are very hard on yourself. In the first house, in Aries, maybe Saturn is asking you, "Where and how can I exercise my sense of courage and individuality? Am I looking after my body and physical fitness properly?"
When you go through a chart this way, you can start to see some elements pulling together. OK-- so maybe your focus on the DC suggests an activity you would enjoy with a partner, like tennis. Then maybe Saturn in the first is asking you to look after your physical fitness more seriously. Both parts of your horoscope get some of what they need.
With such a strong focus on your 6th house, your health should be a major concern to you. Most people who exercise regularly (don't smoke, &c) report feeling better-- and better about themselves. So diet, nutrition, a work-out: these start coming together.
The 6th also deals with service to other people. The best rule I know for curing those lonesome feelings about myself is to try to help another person. Do you or can you volunteer for people who are less fortunate than yourself? (Note that the 6th is also associated with small animals-- perhaps an animal shelter needs volunteers.) Try on the idea that "It's not about me," and see how you can be a blessing to people who would really welcome your attention. There are so many street children, homeless people, battered women, and so on, who could benefit from your time and caring. they will give you all the recognition you deserve.
Your life may not be about whether you've made a "success" of it by your own or a materialistic society's standards. It may be about reaching out a hand to another person.
With your north node in the first house, your personal growth may just be about coming to terms with yourself as who you are as an individual. And God doesn't make mistakes.