(Following is not in accordance with standard horary practice and uses whole sign house format)
I'll use the Lot of Hope (ascendant+mercury-jupiter) to delineate this question:
-LOH falls @ 3 Leo, significator = the Sun
-querent = 1st house = Virgo = Mercury
-quesited (possible relationship) = 7th house = Pisces = Jupiter
-querent's co-significator = Moon
-LOH is in querent's 12th whole sign house = - testimony
-LOH is in quesited's 6th whole sign house = - testimony
-querent's Mercury flows toward the LOH = + testimony
-querent's Moon flows away from the LOH = - testimony
-quesited significator Jupiter flows toward the LOH = + testimony
-LOH significator Sun flows toward Jupiter (+), querent's Mercury flows toward the Sun (+), Moon flows away from the Sun (-) = net + testimony
Results:
Positive = +3 testimonies
Negative = -3 testimonies
Net = 0 (neutral)
Answer: there is a 50/50 indication for having hope in this matter; in other words, at this time the answer to your question is "maybe"...so, to me at least, this says-give it a try, test it out, it is a possibility!