In my experience, i have found neptune to be the least effective from all the stars.
Uranus is very effective in some ways especially when it contacts your natal sun and gives very very undesirable results, for more than two weeks and its effects usually carry over for about a year or so.
Plutos placement shows it effect lightly.
Another point to note: In vedic astrology,they usually ignore these last 3 planets and calculate everything from the basic planets. chiron etc are also ignored.
A good vedic astrologer can give you such details which may never be got from a western astroger. But the thing is that you have to find a good astrologer. Otherwise he will give you incomplete detail.
Vedic astrologer makes a lot of charts too. like janum kundali, navamsa, satsamsa , hora , etc (hope my spelling is right). Western astrologer only makes the natal chart, and sometimes the progressed chart. Some believe in the solar return chart, but which i have not as yet found very useful.